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Duarte, CA
POSTDOCTORAL FELLOW - STRUCTURAL BIOLOGY AND DRUG DISCOVERY - 10034713
Duarte, CACity of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases.
Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise.
A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.
Pay Rate: $34.25 - $37.82 per hour
Join the forefront of groundbreaking research at City of Hope, where we are changing lives and making a meaningful impact in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are united by a shared mission: to contribute to innovative approaches that predict, prevent, and cure disease while helping shape the future of medicine through cutting-edge research.
The Dr. Jeff Perry laboratory in the Beckman Research Institute of City of Hope is seeking a highly motivated Postdoctoral Fellow to join a multidisciplinary drug discovery program focused on a redox-sensitive regulatory protein at the intersection of cellular stress responses, inflammation, and metabolic disease, including diabetes. This project aims to develop first-in-class small-molecule modulators of a protein that links oxidative stress to inflammatory signaling pathways, with strong therapeutic potential in metabolic and inflammatory disorders.
As a successful candidate, you will:
Use X-ray crystallography to support structure-guided drug design, lead recombinant protein expression and purification, and conduct quantitative biophysical and biochemical binding studies, such as SPR, ITC, and DSF.
Collaborate in a highly integrated research environment that brings together structural biology, chemical biology, and translational science.
Your qualifications should include:
Ph.D. in life sciences, biomedical sciences, structural biology, biochemistry, or a related discipline is required.
Prior experience in protein biochemistry and X-ray crystallography is essential.
Familiarity with redox biology, inflammatory signaling, or fragment-based discovery approaches is advantageous.
Demonstrated record of successful research projects and publications.
Excellent analytical and problem-solving skills.
Strong communication and collaboration skills.
City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.
City of Hope is an equal opportunity employer.
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.
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