POSTDOCTORAL FELLOW - CAR T CANCER RESEARCH - 10032349

Duarte, CA

City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

Pay Rate: $34.0 - $37.55 per hour

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The Chintan Parekh Lab is seeking a Postdoctoral Fellow to work on research projects focused on defining mechanisms underlying interactions between CAR T-cells and the bone marrow microenvironment. This project will use spectral flow cytometry, in vitro and in vivo CAR T-cell assays and gene knockdown, overexpression, and CRISPR knockout studies.

The lab focuses on mechanisms underlying human T-cell development and lymphoid leukemogenesis and the application of these mechanistic insights to the development of novel anti-cancer immunotherapy approaches, methods to improve T-cell recovery following bone marrow transplantation, and anti-leukemia therapies. They investigate cellular and molecular mechanisms via a combination of computational biology and functional in vitro and in vivo studies of human normal blood progenitor cells, immune cells, and leukemia cells. The lab delineates complex layers of biological regulation by integrating data from a wide range of studies, including transcriptomic, epigenomic, proteomic, T-cell receptor rearrangement sequencing, high dimensional spectral flow cytometry, in vitro organoid, and in vivo xenotransplantation assays. The Parekh lab is funded by R01 grants from the National Institute of Health and has publications in high impact journals like Nature Immunology and Immunity.

To learn more about Dr. Chintan Parekh please visit here.

As a successful candidate you will:

· Design and conduct of experiments related to current projects

· Analyze primary data

· Prepare manuscripts and other research presentations.

Your qualifications should include:

· PhD or M.D. in Immunology, Cancer Biology or related field

· Experience in flow cytometry is preferred

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.