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POSTDOCTORAL FELLOW - CANCER IMMUNOTHERAPIES - 10034053
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Duarte, CA
POSTDOCTORAL FELLOW - CANCER IMMUNOTHERAPIES - 10034053
Duarte, CACity of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases.
Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise.
A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.
Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
A Postdoctoral Fellowship opportunity is available in the lab of Dr. Mingye Feng. His laboratory employs cutting-edge techniques to understand mechanisms of macrophages in cancer immunosurveillance, identify immune checkpoints and ligands on various hematopoietic malignant and solider tumor cells with high-throughput screening and protein engineering approaches developed in the lab, and develop novel cancer immunotherapies targeting metastatic cancer cells. Cancer immunotherapy is one of the most important breakthroughs in the development of cancer treatment approaches. As one of the largest populations of immune cells in human body and the major components of primary tumors and the metastatic sites, macrophages are key effectors mediating tumor immunosurveillance. Macrophage-based cancer immunotherapy is considered one of the most promising fields in cancer immunology and the next generation of cancer immunotherapy. Recent publications in the Feng lab include Advanced Science, 2026; Nature communications, 2025; Blood, 2022; Science Advances, 2022; JITC, 2021; etc.
Translational medicine is highly promoted at City of Hope, and the lab is well supported by multiple grants from NIH and other research foundations. The lab is also collaborating with clinicians at the Helford Clinical Research Hospital at City of Hope to translate research work in the laboratory to clinically viable agents and therapies.
As a successful candidate you will:
· Utilize a combination of cell biological, molecular biological, cell engineering and immunological assays, large-scale high-throughput screening approaches (CIRSPR screen, drug screen, etc.) and in vivo preclinical models to study interactions between cancer cells and macrophages and develop novel macrophage-mediated cancer immunotherapies. All the research platforms have been well established in the lab.
Your qualifications should include:
· PhD or M.D. in relevant field to include but not limited to cancer, immunology, or cell biology
· Strong background in cell biology, cancer biology and/or immunology
· Excellent verbal and written skills and integral working ethics.
City of Hope is an equal opportunity employer.