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POSTDOCTORAL FELLOW - MALIGNANT BRAIN TUMOR RESEARCH - 10031457

Duarte, CA
Prize Drawing
Prize Drawing

City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases. 

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise. 

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.


Pay Rate: $34.0 - $37.55 per hour

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

A Postdoctoral Fellowship opportunity is available in the lab of Dr. Behnam Badie.  Malignant brain tumors urgently need therapies that can cross the blood-brain barrier, silence pathogenic signaling, and spare healthy tissue. Our lab is working in this direction, addressing the combination of oligonucleotide design, smart nanocarriers, ultra-high-throughput screening, and structural biophysics. We are looking for a postdoctoral scientist who will work at the crossover of chemistry, biology, and engineering to advance these technologies from concept to pre-clinical proof-of-concept.

For more information on Dr. Badie’s lab please visit here

As a successful candidate you will:

·         Design ASOs, siRNAs, or aptamers that include chemical stabilizers and targeting motifs for delivery and persistence of activity in the brain-tumor microenvironment.

·         Formulate and optimize liposomes and polymeric/hybrid nanoparticles for delivery across the BBB and release in vivo where targeted.

·         Design and validate biochemical and cell-based readouts (including reporter lines) to quantify inhibition of trans-membrane proteins like RAGE and its co-receptors.

·         Program our HTS robotics platform to interrogate small-molecule libraries; triage hits, coordinate SAR follow-up, and shepherd hit-to-lead evolutions.

·         Express and purify soluble and membrane proteins from bacteria, insect (Sf9/Baculovirus) and mammalian (Expi293/CHO) systems; systematically troubleshoot folding, yield, and PTMs.

·         Measure affinity/kinetics by SPR and ITC, solve structures by X-ray (or cryo-EM), and perform SDS-PAGE / Western blotting and complementary biophysics.

·         Use phage, yeast, or mRNA display to isolate antibodies, VHHs, or alternative scaffolds; employ NGS to map enriched clones and advance leads into expression/characterization.

·         Draft figures, manuscripts, and grant sections (NIH, DoD, foundations); present at conferences; coach graduate students and technicians, and help maintain a collaborative, deadline-driven lab culture.

Your qualifications should include:

·         Ph.D. (or imminent completion) in Molecular Biology, Biochemistry, Chemical/Biomedical Engineering, Pharmaceutical Sciences, or a closely related field

·         Hands-on expertise in at least two of the following areas:

o   Oligonucleotide therapeutics or nucleic-acid chemistry

o   Nanoparticle / liposome formulation and characterization

o   HTS assay development and robotic screening

o   Recombinant protein expression in multiple hosts

o   Biophysical methods (SPR, ITC, structural biology)

o   Antibody or scaffold display technologies

·         Track record of first-author publications in peer-reviewed journals

·         Strong data-analysis skills (e.g., Prism, Python/R, HTS analytics) and clear scientific writing/presentation ability

·         Genuine enthusiasm for mentoring and cross-disciplinary teamwork

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.

To learn more about our Comprehensive Benefits, please CLICK HERE.

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