POSTDOCTORAL FELLOW - HEMATOLOGICAL MALIGNANCIES AND TRANSLATIONAL SCIENCES - 10025412

Monrovia, CA

City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

Pay Rate: $34.0 - $37.55 per hour

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

The laboratories of Drs. Bin (Amber) Zhang and Guido Marcucci in the Department of Hematological Malignancies and Translational Sciences are looking for highly motivated and creative Postdoctoral Fellow. You will join a well-established group focused on conducting and completing projects leading to publications in high-impact journals. Our labs have been focused on exploring the molecular mechanisms of leukemogenesis and evolution, discovery of novel therapeutic targets, and development of novel therapeutic strategies, including novel antibodies and CART cells, in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and acute lymphoblastic leukemia (ALL).

As a successful candidate you will:

· Lead projects by designing and performing experimental procedures

· Manage data, analyze, and report findings

· Write scientific papers and grants

· Work with PI and other team members to perform experiments in vitro and in vivo

· In vitro skills:

o Cell culture, RNA/DNA extraction, protein extraction, western blot, immunoprecipitation, Immunofluorescence, RT-qPCR, seahorse assay, lentivirus production and cell transduction, ELISA, CART production, CRISPR/Cas9 technology

· In vivo skills:

o Routes of drug administration: oral gavage, intraperitoneal, retro-orbital, subcutaneous, or tail vein injections

o Tissue collection: blood collection, organ harvesting (spleen, bone marrow, liver, etc.)

Your qualifications should include:

· PhD or M.D.

· Experience with molecular signaling, cancer biology, immunity, and mouse work is preferred

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here