City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

Thank you for your interest. Please note, the purpose of this posting is to recruit for on-going and future positions.

For consideration, please send a single PDF that includes your CV, a cover letter briefly highlighting your previous research accomplishments and future research goals, and contact information of three scientific mentors (references) to Dr. Jianjun Chen at jianchen@coh.org and Dr. Jeff Perry at jperry@coh.org
Pay Rate: $34.00-$37.54 per hour

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

We currently have a Postdoctoral Fellowship position in protein crystallography and drug discovery that is available as a joint position in the labs of Dr. Jianjun Chen, Chair of Department of Systems Biology and Deputy Director of Center for RNA Biology and Therapeutics, and Dr. Jeff Perry, Assistant Professor in the Department of Molecular Diagnostics and Experimental Therapeutics, at City of Hope Medical Center in Los Angeles, California. The research is focused on fragment - and small molecule-based drug discovery approaches against RNA/DNA epigenetic targets, RNA methylation and post-transcriptional regulation. The research includes determining structures of fragment, RNA probe, and small molecule:protein target co-complexes and using biophysical approaches, including thermal shift assays, isothermal calorimetry and/or surface plasmon resonance.

For more information about Drs. Chen and Perry’s labs, please click on the links below:

Jianjun Chen Lab

Jeff Perry Lab

As a successful candidate, you will:

Devise, plan, document and advance science-based projects in structural biology and drug discovery.
Generate data for grant applications and prepare manuscripts for publication.
Work in close collaboration with other team members and external collaborators, including presentation of progress internally or externally.
Train and supervise technical staff.
Have the unique possibility to drive research towards the development of novel cancer therapies at the interface of science and translation to the clinic and publish high-impact journals.

Your qualifications should include:

A PhD in biochemistry, biophysics, or related discipline with a strong background in protein crystallography is required.
Evidence of scientific rigor and excellence as documented by peer-reviewed publications.
Ability to work in a fast-paced research environment and manage multiple projects and collaborations.
Strong team player with excellent communication skills and fluency in English, both spoken and written.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.

To learn more about our Comprehensive Benefits, please CLICK HERE.

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POSTDOCTORAL FELLOW - STRUCTURAL BIOLOGY AND DRUG DISCOVERY AGAINST EPIGENETIC TARGETS - 10027764