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POSTDOCTORAL FELLOW OR STAFF SCIENTIST - PROTEIN CHEMISTRY, CRYSTALLOGRAPHY AND STRUCTURE DETERMINATION - 10027093

Duarte, CA
Prize Drawing
Prize Drawing

City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases. 

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a wholly owned subsidiary, was launched in 2019 and is dedicated to serving employers and their health care partners by providing access to City of Hope’s exceptional cancer expertise. 

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

Thank you for your interest.  Please note, the purpose of this posting is to recruit for on-going and future positions. 

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research. 

The John Williams research lab at City of Hope is seeking a Postdoctoral Fellow or a Staff Scientist to join an innovative team. Our research primarily focuses on structural and biophysical methods to identify sources of energy additivity and multivalency in macromolecular complexes and use these properties to develop new tools and novel therapeutics.

As a successful candidate, you will:

·       Determine structure of modified antibodies with immune receptors

·       Apply yeast display to stabilize and subsequent deimmunize proteases

·       Create additional antibody variants to maximize the therapeutic activity in a clinical setting

Your qualifications should include:

·       Ph.D. degree chemistry, biochemistry, structural biology, biophysics or a related discipline is required.

·       Knowledge of protein engineering (cloning, expression, purification), crystallography (crystallization, optimization, data collection and structure determination), biochemistry (enzyme kinetics) and biophysics (Surface Plasmon Resonance, Iosthermal Ttitration Calorimetry

Additional Information:

·       To apply to the position, please send your CV or resume to Dr. John Williams at jcwilliams@coh.org for consideration.

·       Candidates will be assessed for the suitable level based on their relevant experience.

·       Postdoctoral Fellow - Pay Rate: $34.00 – $37.54

·       Staff Scientist – Pay Rate: $38.67 – $123.37

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here.

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